Articles Tagged With:
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Viruses, Newborns, and Liver Failure
Neonatal liver failure due to herpesvirus infection is rare but can be severe. Herpes simplex virus 1 (HSV-1) is a more likely cause than HSV-2. Only about two-thirds of affected patients survive, despite recommended treatment with parenteral acyclovir.
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Metformin Reduces SARS-CoV-2 Viral Load in Outpatients with COVID-19
A randomized, placebo-controlled clinical trial of outpatients with COVID-19 found that metformin reduced SARS-CoV-2 viral load 3.6-fold compared to placebo, while ivermectin and fluvoxamine showed no benefit.
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The Rise of Oropouche Virus
Oropouche virus is an arthropod-borne virus that has been primarily endemic to the Amazon region. The incidence of Oropouche virus disease has significantly increased over the past few years, and recent outbreaks have been reported in areas without previous endemic transmission and have led to fatalities and vertical transmission resulting in adverse pregnancy outcomes.
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How Old Is Atherosclerosis?
Computed tomography of mummified human remains exhibits vascular calcium in almost 40% across multiple eras and geographies, which included <br />non-elites.
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Marantic Endocarditis Revisited
A single institution case series of cancer-associated thrombotic endocarditis has shown that it most frequently presents as a systemic embolism and is detected largely by transesophageal echocardiography, which displays mobile masses attached to thickened mitral and aortic valves.
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Clarifying the Risk of Aortic Aneurysm Development
A large, cross-sectional study of adults by aortic computed tomography angiography has shown that aortic aneurysms (AAs) are more frequent in men than women. While increasing age and body surface area were common risk factors for AA, hypertension was associated with thoracic AA and hypercholesterolemia and smoking were risk factors for abdominal AA.
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Antithrombotic Treatment for Atrial Fibrillation After Acute Coronary Events
An analysis of the AUGUSTUS trial comparing a P2Y12 inhibitor plus four combinations of double or triple therapy with apixaban, aspirin, and a vitamin K antagonist in patients with atrial fibrillation and a recent acute coronary event or percutaneous coronary intervention has shown that a P2Y12 inhibitor plus apixaban exhibited the lowest rate of major adverse events and major bleeding events.
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Poor Diabetes Control Associated with Poorer Coronary Stent Outcomes
In this large, observational study of diabetic patients with coronary stents, poorer glycemic control as measured by hemoglobin A1c was associated with stepwise hazard for stent failure over a period of more than six years, primarily driven by in-stent restenosis.
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Many Ethics Concerns with Involuntary Psychiatric Holds
Hospitals continue to see a surge of psychiatric patients. Some end up being held involuntarily, raising multiple ethical concerns.
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Ethical Informed Consent if Resident Is Involved in Surgery
Given conflicting opinions about disclosing trainee participation in surgery, Nhon Le, MD, and colleagues developed an ethical framework to guide surgeons in disclosing resident involvement during the informed consent process.